I've just finished this book and came here to see if my reading was similar to others, but I've seen no reference to my interpretation of the book which may suggest I am wrong.
Ignoring the gender issues in the book (hard when that is the main idea), I believe that Simon is, in fact, meant to be the Disc's Einstein. He breaks down the behaviour of the entire disc into numbers and equations, and the others all can see that it all makes a lot of sense even if they can't understand it.
The creatures from the Dungeon Dimensions are probably a reference to the powers behind Einstein's theory, i.e. the dangers of nuclear technology. The wisdom to know all about the science but not to use it reflects the same situation with regards to nuclear weaponry and maybe even nuclear power etc.
The new science that Esk and Simon went off to study is probably relativity and quantum physics.
Am I way off track or was this just too obvious to be mentioned here?
Cheers,
BJ